Research, Innovation & Impact

Shrestha V, Yobi A, Slaten ML, Chan YO, Holden S, Gyawali A, Flint-Garcia S, Lipka AE, Angelovici R. Multiomics approach reveals a role of translational machinery in shaping maize kernel amino acid composition. Plant Physiol. 2022 Jan 20;188(1):111-133. doi: 10.1093/plphys/kiab390. PMID: 34618082; PMCID: PMC8774818.

Zandalinas SI, Song L, Nechushtai R, Mendoza-Cozatl DG, Mittler R. The Cluster Transfer Function of AtNEET Supports the Ferredoxin-Thioredoxin Network of Plant Cells. Antioxidants (Basel). 2022 Aug 6;11(8):1533. doi: 10.3390/antiox11081533. PMID: 36009251; PMCID: PMC9405330.

Xavier LR, Almeida FA, Pinto VB, Passamani LZ, Santa-Catarina C, de Souza Filho GA, Mooney BP, Thelen JJ, Silveira V. Integrative proteomics and phosphoproteomics reveals phosphorylation networks involved in the maintenance and expression of embryogenic competence in sugarcane callus. J Plant Physiol. 2022 Jan;268:153587. doi: 10.1016/j.jplph.2021.153587. Epub 2021 Dec 8. PMID: 34906795.

Mahalingam S, Shankar G, Mooney BP, Singh K, Santhoshkumar P, Sharma KK. Deletion of Specific Conserved Motifs from the N-Terminal Domain of αB-Crystallin Results in the Activation of Chaperone Functions. Int J Mol Sci. 2022 Jan 20;23(3):1099. doi: 10.3390/ijms23031099. PMID: 35163023; PMCID: PMC8834691.

McCrae CS, Curtis AF, Cottle A, Beversdorf DB, Shenker J, Mooney BP, Popescu M, Rantz M, Groer M, Stein P, Golzy M, Stearns MA, Simenson A, Nair N, Rowe MA. Impact of Web-Based Cognitive Behavioral Therapy for Insomnia on Stress, Health, Mood, Cognitive, Inflammatory, and Neurodegenerative Outcomes in Rural Dementia Caregivers: Protocol for the NiteCAPP CARES and NiteCAPP SHARES Randomized Controlled Trial. JMIR Res Protoc. 2022 Jun 14;11(6):e37874. doi: 10.2196/37874. PMID: 35700020; PMCID: PMC9240954.

Bayati M, Hsieh HY, Hsu SY, Li C, Rogers E, Belenchia A, Zemmer SA, Blanc T, LePage C, Klutts J, Reynolds M, Semkiw E, Johnson HY, Foley T, Wieberg CG, Wenzel J, Lyddon T, LePique M, Rushford C, Salcedo B, Young K, Graham M, Suarez R, Ford A, Lei Z, Sumner L, Mooney BP, Wei X, Greenlief CM, Johnson MC, Lin CH. Identification and quantification of bioactive compounds suppressing SARS-CoV-2 signals in wastewater-based epidemiology surveillance. Water Res. 2022 Aug 1;221:118824. doi: 10.1016/j.watres.2022.118824. Epub 2022 Jul 5. PMID: 35830746; PMCID: PMC9253601.

Chen S, Siedhoff HR, Zhang H, Liu P, Balderrama A, Li R, Johnson C, Greenlief CM, Koopmans B, Hoffman T, DePalma RG, Li DP, Cui J, Gu Z. Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors. Neurobiol Dis. 2022 Apr;165:105634. doi: 10.1016/j.nbd.2022.105634. Epub 2022 Jan 22. PMID: 35077822.
 

Grobman M, Rindt H, Reinero CR. Proteomic Characterization of Canine Gastric Fluid by Liquid Chromatography-Mass Spectrometry for Development of Protein Biomarkers in Regurgitation, Vomiting, and Cough. Front Vet Sci. 2021 Jul 7;8:670007. doi: 10.3389/fvets.2021.670007. PMID: 34307522; PMCID: PMC8292676.

Dynamic role of phospholipases A2 in health and diseases in the central nervous system.
Grace Y. Sun, Xue Geng, Tao Teng, Bo Yang, Michael K. Appenteng, C. Michael Greenlief, and James C. Lee, Cells, 2021, 10: 2963.

Cyanogenic glycoside analysis in American elderberry.
Michael K. Appenteng, Ritter Krueger, Mitch C. Johnson, Harrison Ingold, Richard Bell, Andrew L. Thomas, and C. Michael Greenlief, Molecules, 2021, 23: 1384.

Docosahexaenoic acid (DHA) supplementation alters phospholipid species and lipid peroxidation products in adult mouse brain, heart, and plasma.
Grace Y. Sun, Michael K. Appenteng, Runting Li, Taeseon Woo, Bo Yang, Chao Qin, Meixia Pan, Magdalena Cieślik, Jiankun Cui, Kevin L. Fritsche, Zezong Gu, Matthew Will, David Beversdorf, Agata Adamczyk, Xianlin Han, and C. Michael Greenlief, NeuroMolecular Medicine, 2021, 23: 118-129.

NaTrxh is an essential protein for pollen rejection in Nicotiana by increasing S-RNase activity.
Torres-Rodríguez MD, Cruz-Zamora Y, Juárez-Díaz JA, Mooney B, McClure BA, Cruz-García F.
Plant J. 2020 Aug;103(4):1304-1317. doi: 10.1111/tpj.14802. Epub 2020 Jun 13. PMID: 32392366.

Label-Free Quantitative Phosphoproteomics Reveals Signaling Dynamics Involved in Embryogenic Competence Acquisition in Sugarcane.
Almeida FA, Passamani LZ, Santa-Catarina C, Mooney BP, Thelen JJ, Silveira V.
J Proteome Res. 2020 Oct 2;19(10):4145-4157. doi: 10.1021/acs.jproteome.0c00652. Epub 2020 Sep 23. PMID: 32964716.

NaTrxh Is an Essential Protein for Pollen Rejection in Nicotiana by Increasing S-RNase Activity
Maria D Torres-Rodríguez, Yuridia Cruz-Zamora, Javier A Juárez-Díaz, Brian Mooney, Bruce A McClure, Felipe Cruz-García
Plant J. May 11. doi: 10.1111/tpj.14802

The complex response of free and bound amino acids to water stress during the seed setting stage in Arabidopsis.
Abou Yobi, Clement Bagaza, Albert Batushansky, Vivek Shrestha, Marianne L. Emery, Samuel Holden, Sarah Turner‐Hissong, Nathan D. Miller, Thomas P. Mawhinney, Ruthie Angelovici
Plant J, 102, 4, 838-855

Quantitative proteomic analysis of chikungunya virus-infected Aedes aegypti reveals proteome modulations indicative of persistent infection.
Y Cui, P Liu, BP Mooney, AWE Franz
Journal of Proteome Research 19, 6, 2443-2456

Quantitative proteomics reveals docosahexaenoic acid-mediated neuroprotective effects in lipopolysaccharide-stimulated microglial cells.
Bo Yang, Runting Li, Pei N Liu, Xue Geng, Brian P Mooney, Chen Chen, Jianlin Cheng, Kevin L Fritsche, David Q Beversdorf, James C Lee, Grace Y Sun, C Michael Greenlief
J. Proteome Res 19, 6, 2236–2246

Suppression of Organismal Death Pathway in the Heart Tissues of Diabetic Mice by NP‐6A4, A Peptide Agonist of the Angiotensin II Receptor AT2R.
L Pulakat, A Belenchia, B Mooney, VG DeMarco
The FASEB Journal 34 (S1), 1-1

Identification of health-promoting bioactive phenolics in black walnut using cloud-based metabolomics platform.
Danh C Vu, Jihyun Park, Khanh-Van Ho, Lloyd W Sumner, Zhentian Lei, C Michael Greenlief, Brian Mooney, Mark V Coggeshall, Chung-Ho Lin
Journal of Food Measurement and Characterization 14 (2), 770-777

Characterization and regulation of extracellular vesicles in the lumen of the ovine uterus
Eleanore V O’Neil, Gregory W Burns, Christina R Ferreira, Thomas E Spencer
Biology of Reproduction, Volume 102, Issue 5, May 2020, Pages 1020–1032

Analysis of the uterine lumen in fertility-classified heifers: II. Proteins and metabolites
Joao G N Moraes, Susanta K Behura, Jeanette V Bishop, Thomas R Hansen, Thomas W Geary, Thomas E Spencer
Biology of Reproduction, Volume 102, Issue 3, March 2020, Pages 571–587

EPSIN1 Modulates the Plasma Membrane Abundance of FLAGELLIN SENSING2 for Effective Immune Responses
Carina A. Collins, Erica D. LaMontagne, Jeffrey C. Anderson, Gayani Ekanayake, Alexander S. Clarke, Lauren N. Bond, Daniel J. Salamango, Peter V. Cornish, Scott C. Peck, Antje Heese
Plant Physiol. 2020 Apr; 182(4): 1762–1775.

Effects of Docosahexaenoic Acid and its Peroxidation Product on Amyloid-β Peptide-Stimulated Microglia
Xue Geng, Bo Yang, Runting Li, Tao Teng, Mary Jo Ladu, Grace Y. Sun, C. Michael Greenlief, and James C. Lee, 
Molecular Neurobiology, 57, 1085-1098 (2020), doi.org/10.1007/s12035-019-01805-4

Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration (Review)
Hailong Song, Jiankun Cui, Valeri V. Mossine, C. Michael Greenlief, Kevin Fritsche, Grace Y. Sun, and Zezong Gu,
Experimental and Therapeutic Medicine, 19, 1554-1559 (2020), doi.org/10.3892/etm.2019.8389.

Harpagophytum procumbens extract ameliorates allodynia and modulates oxidative and antioxidant stress pathways in a rat model of spinal cord injury
Garrett Ungerer, Jiankun Cui, Tina Ndam, Mikeala Bekemeier, Hailong Song, Runting Li, Heather R. Siedhoff, Bo Yang, Michael K. Appenteng, C. Michael Greenlief, Dennis K. Miller, Grace Y. Sun, William R. Folk, and Zezong Gu
NeuroMolecular Medicine, 22, 278-292 (2020), doi.org/10.1007/s12017-019-08585-z.

12-Hydroxy-Jasmonoyl-l-Isoleucine Is an Active Jasmonate That Signals through CORONATINE INSENSITIVE 1 and Contributes to the Wound Response in Arabidopsis
Arati N Poudel, Rebekah E Holtsclaw, Athen Kimberlin, Sidharth Sen, Shuai Zeng, Trupti Joshi, Zhentian Lei, Lloyd W Sumner, Kamlendra Singh, Hideyuki Matsuura, Abraham J Koo
Plant and Cell Physiology, 60 (10) 2152–2166

Adaptive responses of amino acid metabolism to the combination of desiccation and low nitrogen availability in Sporobolus stapfianus
Abou Yobi, Albert Batushansky, Melvin J. Oliver & Ruthie Angelovici
Planta volume 249, pages1535–1549(2019)

Compartmentalization of the Proteasome-Interacting Proteins During Sperm Capacitation
Michal Zigo, Pavla Manaskova-Postlerova, Vera Jonakova, Karl Kerns, Peter Sutovsky
Sci Rep. 2019 Aug 29;9(1):12583.

Comparative Proteomic Analysis Unveils Critical Pathways Underlying the Role of Nitrogen Fertilizer Treatment in American Elderberry
Bo Yang, Andrew L. Thomas, and C. Michael Greenlief,
Proteomes. 7(1): 10.

Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice
Bo Yang, Runting Li, Taeseon Woo, Jimmy D. Browning, Jr., Hailong Song, Zezong Gu, Jiankun Cui, James C. Lee, Kevin L. Fritsche, David Q. Beversdorf, Grace Y. Sun, and C. Michael Greenlief
Metabolites. 2019 Mar; 9(3): 40.

Quercetin Potentiates Docosahexaenoic Acid to Suppress Lipopolysaccharide-induced Oxidative/Inflammatory Responses, Alter Lipid Peroxidation Products, and Enhance the Adaptive Stress Pathways in BV-2 Microglial Cells
Grace Y. Sun, Runting Li, Bo Yang, Kevin L. Fritsche, David Q. Beversdorf, Dennis B. Lubahn, Xue Geng, James C. Lee, and C. Michael Greenlief
Int J Mol Sci. 2019 Feb; 20(4): 932.

Tasselseed5 overexpresses a wound-inducible enzyme, ZmCYP94B1, that affects jasmonate catabolism, sex determination, and plant architecture in maize
China Lunde, Athen Kimberlin, Samuel Leiboff, Abraham J. Koo, and Sarah Hake
Commun Biol. 2019; 2: 114.

From Analysis of Ischemic Mouse Brain Proteome to Identification of Human Serum Clusterin as a Potential Biomarker for Severity of Acute Ischemic Stroke
Hailong Song, Hui Zhou, Zhe Qu, Jie Hou, Weilong Chen, Weiwu Cai, Qiong Cheng, Dennis Y Chuang, Shanyan Chen, Shuwei Li, Jilong Li, Jianlin Cheng, C. Michael Greenlief, Yuan Lu, Agnes Simonyi, Grace Y Sun, Chenghan Wu, Jiankun Cui, and Zezong Gu
Translational Stroke Research, 2019; 10: 546-556

Defects in long‐chain 3‐hydroxy acyl‐CoA dehydrogenase lead to hepatocellular carcinoma: A novel etiology of hepatocellular carcinoma
Tripti Khare, Sharad Khare, Jerry J. Angdisen, Qiong Zhang, Alexei Stuckel, Brian P. Mooney, Suzanne E. Ridenhour, Raad S. Gitan, Ghassan M. Hammoud, Jamal A. Ibdah
Int J Cancer Mar 1 doi: 10.1002/ijc.32943

A High‐Throughput Absolute‐Level Quantification of Protein‐Bound Amino Acids in Seeds
Abou Yobi and Ruthie Angelovici
Current Protocols, 3 (4), e20084

Docosahexaenoic acid (DHA): an essential nutrient and a nutraceutical for brain health and diseases
Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey Yao, James C. Lee, and David Q. Beversdorf
Prostaglandins, Leukotrienes, and Essential Fatty Acids, 136, 3-13 (2018), doi.org/10.1016/j.plefa.2017.03.006.

Unveiling anti-oxidative and anti-inflammatory effects of 4-hydroxyhexenal and 4-hydroxynonenal and their regulation by docosahexaenoic acid and lipopolysaccharide in microglial cells
Bo Yang, Runting Li, C. Michael Greenlief, Agnes Simonyi, Kevin L. Fritsche, Zezong Gu, Jiankun Cui, David Q. Beversdorf, and Grace Y. Sun
Journal of Neuroinflammation, 15, 202 (2018), doi.org/10.1186/s12974-018-1232-3.