Bruker timsTOF Pro 2 Image Hybrid trapped ion-mobility spectrometry, quadrupole, time-of-flight LC-MS+MS/MS Accurate mass, high resolution, instrument (routinely <10 parts per million, 50,000 resolution) High-coverage global quantitative proteomics PTM mapping and quantitation Higher sensitivity than the timsTOF Pro Bruker timsTOF Pro Image Hybrid trapped ion-mobility spectrometry, quadrupole, time-of-flight LC-MS+MS/MS Accurate mass, high resolution, instrument (routinely <10 parts per million, 50,000 resolution) High-coverage global quantitative proteomics PTM mapping and quantitation ThermoFisher Scientific LTQ Orbitrap XL Image Hybrid ion trap, Orbitrap mass spectrometer Accurate mass instrument (routinely < 5 ppm on precursor) High resolution, typically 30,000 for peptides Very high resolution possible (>100,000 at m/z 400) Reversed-phase separation of peptides using integrated Proxeon nano-HPLC ThermoFisher Scientific Quantiva Image Triple quadrupole mass spectrometer Nano-HPLC with ESI source Targeted quantitation of peptides/proteins. Aqua-MRM. Used for relative quantitation between samples, can also be used for absolute quantitation (i.e. µg/mL etc.) by using 13C-labeled peptides as internal standards allowing very accurate quantitation of proteins. Waters Xevo Absolute Image Triple quadrupole mass spectrometer UHPLC with ESI or APCI source High sensitivity and quantitation of targeted compounds in both positive and negative ion modes Part of the Directed Analysis MS Lab Amersham IPGphor & Bio-Rad Protean IEF Image Isoelectric focusing units Amersham SE 600, Ettan DALTsix, & SE62 Image Second-dimension gel electrophoresis and electrophoretic transfer units Gehrke Proteomics Center Instrumentation Services Fees Typical costs Forms Protocols Directed Analysis MS Lab Publications Contact us