Bruker timsTOF Pro 2
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- Hybrid trapped ion-mobility spectrometry, quadrupole, time-of-flight LC-MS+MS/MS
- Accurate mass, high resolution, instrument (routinely <10 parts per million, 50,000 resolution)
- High-coverage global quantitative proteomics
- PTM mapping and quantitation
- Higher sensitivity than the timsTOF Pro
Bruker timsTOF Pro
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- Hybrid trapped ion-mobility spectrometry, quadrupole, time-of-flight LC-MS+MS/MS
- Accurate mass, high resolution, instrument (routinely <10 parts per million, 50,000 resolution)
- High-coverage global quantitative proteomics
- PTM mapping and quantitation
ThermoFisher Scientific LTQ Orbitrap XL
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- Hybrid ion trap, Orbitrap mass spectrometer
- Accurate mass instrument (routinely < 5 ppm on precursor)
- High resolution, typically 30,000 for peptides
- Very high resolution possible (>100,000 at m/z 400)
- Reversed-phase separation of peptides using integrated Proxeon nano-HPLC
ThermoFisher Scientific Quantiva
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- Triple quadrupole mass spectrometer
- Nano-HPLC with ESI source
- Targeted quantitation of peptides/proteins.
- Aqua-MRM. Used for relative quantitation between samples, can also be used for absolute quantitation (i.e. µg/mL etc.) by using 13C-labeled peptides as internal standards allowing very accurate quantitation of proteins.
Waters Xevo Absolute
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- Triple quadrupole mass spectrometer
- UHPLC with ESI or APCI source
- High sensitivity and quantitation of targeted compounds in both positive and negative ion modes
- Part of the Directed Analysis MS Lab
Amersham IPGphor & Bio-Rad Protean IEF
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- Isoelectric focusing units
Amersham SE 600, Ettan DALTsix, & SE62
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- Second-dimension gel electrophoresis and electrophoretic transfer units