image from advanced light microscopy contest winner 2019
Deconvolution everywhere

For a limited time, the ALMC is offering free floating licenses for the Huygens Professional deconvolution software program. Deconvolution is a powerful tool for improving the resolution of fluorescent microscopy images. Now, with this floating license plan, called Huygens Everywhere, you can install Huygens Professional onto a lab or personal computer to perform deconvolution with your widefield or confocal microscopy images from the convenience of your home lab. If you are interested in using Huygens Everywhere or would like to know more about the deconvolution capacities of Huygens Professional, please contact the ALMC staff.

New cryostat and a software upgrade

We are pleased to announce that the ALMC will be acquiring a Leica CM3050 S research cryostat to replace our aging cryostat. Slated for arrival this fall, the Leica CM3050 S is a motorized instrument that will produce sections ranging from 0.5 to 300 microns in thickness. Users will appreciate the new feature of a precise specimen positioning system in the X and Y directions, which will ensure accurate and repeatable orientation of frozen tissue blocks. Moreover, the cryostat offers separate cooling controls for the cryochamber and specimen, enabling optimal sectioning temperatures for a wide range of animal and plant tissues. Together, these features will be useful in preparing samples for immunohistochemistry or in performing the first steps of Visium Spatial Gene Expression profiling. We are extremely grateful to the Interdisciplinary Plant Group (IPG), the Bond Life Sciences Center, and the Division of Research, Innovation, & Impact for providing funding for this much needed instrument. 

Thanks to the further support of the IPG, the core has received an upgrade to its Huygens Professional deconvolution software program. This upgrade will allow investigators to deconvolve wide-field fluorescence images acquired either at the ALMC or in their home labs. It is a perfect complement to the deconvolution software we currently offer for use with images acquired by confocal and STED super-resolution microscopy. Please contact us for additional information.

Equipment

Our equipment and services consist of confocal, super-resolution, digital light-sheet and widefield microscopes, laser capture microdissection, image analysis and processing and sample preparation. We also have an onsite Supply Center stocked with fluorescent secondary antibodies and markers. Consumables for laser capture microdissection are also available. Clients can also special order without shipping fees. We offer a file transfer system for clients to use for temporary file storage.

Learn more about our equipment.

Scheduling

We are open 8 a.m.–5 p.m., Monday through Friday, and closed on university holidays.

Our calendar provides an easy way to view available time slots. To make an appointment, please check for instrument availability on the calendars listed then call 882-4895 to make a reservation for the time and instrument you wish to use.

Schedule time on an instrument.

Images

We have sample images showing the use of our equipment and the resulting image options.

Additionally, each year during Life Sciences Week, ALMC sponsors a contest to select the best image taken in the core during the previous year. Attendees of Life Sciences Week have the chance to vote for one of the selected images displayed on the ALMC poster during the research poster sessions. Winners are announced at the luncheon for poster first authors at the conclusion of Life Sciences Week. Beginning in 2001, our winners' images have been posted.

See sample images.

Director
Dr. Alexander Jurkevich (Asst. Dir.)
120 Bond Life Sciences Center, 1201 Rollins Street
573-882-4895