Our mission

The mission of the Molecular Interactions Core (formerly the Structural Biology Core) is to enhance the research infrastructure available to MU life scientists by ensuring sustained access to functional state-of-the-art equipment and expertise in the fields of structural biology, molecular interactions and peptide synthesis.

To accomplish this goal we will:

  • Provide equipment maintenance and infrastructure support for research.
  • Provide structural biology and molecular interactions computational support.
  • Provide an interface for MU researchers seeking structural biology and molecular interactions expertise on campus.

In 2003, a Peptide Synthesis Core was added under the MIC umbrella. The mission of the Peptide Synthesis Core is to provide synthetic peptides in milligram to gram quantities containing non-natural amino acids, metal chelators, peptide-nucleic acid (PNA) conjugates, phospho-peptides, multiple antigen peptides (MAPs), cyclic peptides and fluorescent tagged peptides to researchers across MU.

The Molecular Interactions Core is currently experiencing a growth phase with the addition of new faculty and equipment:

  • $2.1 Million 800 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (early 2008)
  • Rigaku SuperNova with Pilatus 200K detector X-Ray System (2016)
  • New instrumentation for dynamic light scattering and thermophoresis (2017)

Our continuing goal is to provide access to structural biology and molecular interactions resources, facilitate collaborations between faculty with expertise in structural biology and molecular interaction and other MU life scientists, and help strengthen proposals for extramural funding.

Contact information

For questions about protein-ligand interaction (thermophoresis and surface plasmon resonance), dynamic light scattering, zeta potential, particle size determination, X-ray crystallography, custom protein expression and purification for X-ray crystallography, NMR and SAXS, and computer-aided drug design:

Dr. Kamal Singh
Assistant Director, Molecular Interactions Core
Assistant Research Professor, Molecular Microbiology and Immunology
Office: 471b Life Sciences Center
Lab: 442 Life Sciences Center
Phone: 573-882-9024 or 573-884-1281
Email: singhka@missouri.edu

For questions about custom peptide synthesis or custom LC-MS project:

Dr. Fabio Gallazzi
Research Assistant Professor
Office: 471b Life Sciences Center
Lab: 442 Life Sciences Center
Phone: 573-882-9024 or 573-884-1281
Email: gallazzif@missouri.edu

For questions regarding computational support for structural biology and molecular interactions:

Matt Stanley
System Administrator
Office: E3444B Laffere Hall
Phone: 573-882-8796
Email: stanleym@missouri.edu

For any general questions and inquiries about MIC, its goals and commitment to the scientific community:

Dr. Tom Quinn
Director, Molecular Interactions Core
Professor of Biochemistry
Office: 234A Schweitzer Hall
Phone: 573-882-6099
Email: quinnt@missouri.edu

or

Dr. Kamal Singh
Assistant Director, Molecular Interactions Core
Email: singhka@missouri.edu