The Leica CM3050 S is a high-performance motorized research cryostat for sectioning fresh and fixed tissue samples. The instrument has a motorized cutting drive and can produce sections ranging from 0.5 to 300 microns in thickness at temperatures as low as -40°C. The cryostat features a precise specimen positioning system in the X and Y directions for ensuring both accurate and repeatable orientation of frozen tissue blocks. Moreover, the cryostat offers separate cooling controls for the cryochamber and specimen, enabling optimal sectioning temperatures for a wide range of animal and plant tissues. The blade holder takes low- and high-profile disposable blades. Individual low-profile blades, OCT embedding medium, Superfrost Plus glass slides and cryo-molds for tissue embedding are available for purchase at the ALMC.