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Research, Innovation & Impact

The patent puzzle

Mizzou researchers work with Technology Advancement to protect and promote their discoveries.

Mizzou Innovation 2023: Illustration shows scientists completing a puzzle of the U.S. patent seal.

Patenting an invention can be puzzling and complex. It requires both legal and technical expertise, in-depth research to ensure novelty and strategic decisions about where and when to file. Art by Grace Radke

In 2023, the University of Missouri received U.S. patents for a variety of faculty and staff inventions, including novel cancer therapies and a treatment for cardiovascular disease; a plant trait that increases the overall seed oil content in crops; improved engineering materials; a method to bioprint meat that could be a source of protein for countries suffering from war, famine or overpopulation; and a drinking container made with phase-change materials to rapidly cool and maintain liquids at drinkable temperatures.

The Technology Advancement team works with faculty and staff who have discoveries and innovations with commercial potential. Last year, researchers disclosed 113 inventions, which the team evaluated for novelty, utility and market potential.

Technical expertise from MU inventors and an analysis of scientific and patent literature, possible competitors and other factors guide the team’s marketing and intellectual property strategies.

113

New inventions disclosed

16

U.S. patents issued

$18.6M

Licensing income generated

Often, an invention protected by a patent, copyright or trademark is an incentive for a company to invest in commercializing it. This intellectual property also can lead to successful grant proposals, new funding opportunities and partnerships that increase the odds that the research will result in a product or service.

Technology Advancement professionals understand that Mizzou’s intellectual property often sparks commercial ventures. Industry partners interested in further developing a Mizzou invention sign licensing agreements and pay fees. In fact, MU's licensing income totaled $18.6 million in 2023.

In addition, the university was granted 16 U.S. patents for devices, tools, therapeutics and other inventions. Twenty-seven commercial partners licensed and optioned the rights to 59 different innovations. and four startup companies were created with MU-licensed technologies. 

Researchers who think they have an innovation with commercial potential should submit a confidential Invention Disclosure Form to Technology Advancement. Call 573-882-6013 or email techadvancement@missouri.edu with questions.
 

U.S. patents issued in 2023 for Mizzou inventions

Animal and plant biotechnology

Patents

Engineered comestible meat
This method of forming animal muscle either with a bioprinter or other assembly process, produces a food product rich in animal protein. (Patent No. 11,707,077)

  • MU inventors: Gabor Forgacs, Francoise Marga and Karoly Robert Jakab

Increasing plant oil content by improving activity of acetyl-CoA carboxylase
This trait increases the overall seed oil content in crops. (Patent No. 11,802,286)

  • MU inventors: Jay J. Thelen and Matthew Salie

Medium supplement to increase the efficiency of oocyte maturation and embryo culture in vitro
A biological culture media additive for livestock artificial insemination and cloning that yields larger litter sizes. (Patent No. 11,753,622)

  • MU inventors: Ye Yuan, Lee Spate, Randall S. Prather and R. Michael Roberts


Diagnostics and detection

Patents

Detection of biomarkers using plasmonic gratings
This method for producing a low-cost, fast and highly specific substrate includes enhanced fluorescent-based biomarker detection for imaging and medical diagnoses. (Patent No. 11,796,473)

  • MU inventors: Shubhra Gangopadhyay, Sangho Bok, Aaron Wood, Keshab Gangopadhyay, Cherian Joseph Mathai, Syed Barizuddin and Sheila A. Grant


Therapeutics and treatments

Patents

Ayurvedic encapsulated gold nanoparticles, fabrication methods and cancer therapeutic methods 
Plant extracts conjugated to gold nanoparticles using green nanotechnology create cancer therapies consistent with the principles of Ayrvedic-holistic medicine. (Patent No. 11,547,720)

  • MU inventors: Kattesh V. Katti, Menka Khoobchandani, Kavita K. Katti and Aslam Khan

Ceramide nanoliposomes, compositions and methods of using for immunotherapy 
This nanoliposome-loaded C6-ceramide (LipC6) with adoptive cell transfer and immunization is a treatment for liver cancer. (Patent No. 11,559,504)

  • MU inventors: Guangfu Li and Kevin Staveley-O'Carroll

Compositions for the treatment of drug-resistant tumors and methods of use thereof
These methods detect and treat tumors resistant to tyrosine kinase inhibitors (TKIs) using gelatin nanoparticles loaded with siRNAs and TKIs. (Patent No. 11,576,873)

  • MU inventors: Raghuraman Kannan, Dhananjay Suresh, Soumavo Mukherjee, Ajit Prakash Zambre and Anandhi Upendran

Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
These nanoparticles with conjugated antibody fragments are joined to a chemotherapeutic drug for improved targeting of cancer. (Patent No. 11,660,354)

  • MU inventor: Thomas P. Quinn 

Neuraminidase inhibition to improve glycocalyx volume and function to ameliorate cardiovascular diseases in pathologies associated with glycocalyx damage
This neuraminidase inhibition is for the treatment and prevention of cardiovascular stiffening and disease. (Patent No. 11,684,603)

  • MU inventors: Luis A. Martinez-Lemus, Christopher A. Foote and Jaume Padilla


Engineering solutions

Patents

Area selective nanoscale-thin layer deposition via precise functional group lithography
This method deposits nanoscale patterns used in nanoelectronics by applying ionizing radiation. (Patent No. 11,613,807)

  • MU inventors: Matthew R. Maschmann and Matthias J. Young

Photonuclear transmutation doping in gallium-based semiconductor materials 
This method makes high bandgap, gallium-based power transistors using gamma rays. (Patent No. 11,551,932)

  • MU inventors: Jae Wan Kwon and Quang Nguyen

Composite material with high dielectric constant and use in biocompatible devices
This biocompatible implantable material with high dielectric constant could be used in medical devices, such as an implantable antenna, probe, sensor or electrodes. (Patent No. 11,844,881)

  • MU inventors: Kevin A. O'Connor and Randy Curry


Devices and tools

Patents

Drinking container with different temperature zones
This drinking container utilizes phase-change materials to rapidly cool and maintain liquids at drinkable temperatures. (Patent No. 11,672,381)

  • MU inventor: Bill Ma

Heat exchanging thermal liquid container
A drinking container utilizing phase-change materials that rapidly cools and maintains liquids at drinkable temperatures. (Patent No. 11,840,659)

  • MU inventor: Bill Ma

Lid with automatic open and close retention mechanism
This mug lid is designed to work in conjunction with the novel drinking container described in Patents 11,672,381, 11,647,864 and 11,647,864.  (Patent No. 11,603,238)

  • MU inventor: Bill Ma

Thermal liquid container system with heat loss prevention lid
This drinking container and lid utilizes phase-change materials that rapidly cool and maintain liquids at drinkable temperatures. (Patent No. 11,647,864)

  • MU inventor: Bill Ma