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Limited Submission Announcements

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The National Heart, Lung, and Blood Institute (NHLBI) and National Human Genome Research Institute (NHGRI) solicit grant applications for Development and Application of New Technologies to Targeted Genome-wide Resequencing in Well-Phenotyped Populations. The sequencing targets are primarily all exons of the 20,000 protein coding genes identified as RefSeq genes in Entrez Gene database at the National Center for Biotechnology Information (NCBI), which account for 1 to 2 percent of the human genome, but could include other types of functional units such as microRNA and regulatory elements. The NHLBI intends to create a public resource that will host individual sequencing information along with phenotype data of thousands of selected individuals from its well-phenotyped populations.

The purpose of developing this resequencing application is to enable the sequencing of thousands of individual DNA samples in NHLBI's well-phenotyped populations in a cost-effective manner. Applicants must therefore demonstrate the potential to reduce costs towards this goal, while providing data of sufficient quality for distinguishing sequence variants. This FOA is intended to stimulate advances in all critical elements of a resequencing pipeline, including sample preparation. Since any error or bias introduced at this step could be amplified dramatically in subsequent steps, a carefully standardized procedure of sample preparation is required.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 4:00 pm Friday, February 1, 2008. Letters of intent should be limited to a 3-page description of the proposed project, including 1) description of methodology and 2) how you will address the critical issues of target capture, sequencing, quality, cost, scalability, integration of pipelines, and data management and analysis.


The total amount to be awarded is $12 million over two years. The anticipated number of awards is three to four.

MU Deadline:

4:00 p.m., Friday, February 1, 2008

Sponsor Deadlines:

February 28, 2008

URL for more information:

This notice is being sent to deans, directors, and chairs in computer, health, and life sciences. Please forward it to faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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