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HHS Annual Estimates of Influenza Vaccine Effectiveness for Preventing Laboratory-Confirmed Medically Attended Outcomes in the United States

The Centers for Disease Control are seeking applications to conduct annual assessments of the effectiveness of licensed influenza vaccines against laboratory-confirmed medically attended influenza infections diagnosed by viral culture and RT-PCR. Results of these assessments must be available for public health use by the September following the conclusion of the influenza season. The populations to be studied should include those for whom CDC's Advisory Committee on Immunization Practices (ACIP) recommends receipt of trivalent inactivated influenza vaccine or live attenuated influenza vaccine. Influenza-related complications are greatest among those aged 65 years and older. Each applicant must demonstrate the ability to enroll sufficient numbers of laboratory-confirmed cases of influenza among persons aged 65 years and older to estimate vaccine effectiveness, based on conservative estimates of annual attack rates, vaccine coverage, and medical care utilization.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 4:00 pm Friday, January 11, 2008. Letters of intent should be limited to a 3-page description of the proposed project, including 1) anticipated patient enrollment numbers and plans to assess the effectiveness of influenza vaccines against laboratory-confirmed influenza infections; 2) the viral culture, RT-PCR, and other laboratory methods to be used; 3) methods to provide both an interim estimate of vaccine effectiveness and more detailed final results; 4) plans for obtaining and validating vaccination data; and 5) if applicable, plans to collect, process, store, and ship paired serum specimens to a reference laboratory designated by CDC.


T $500,000 to $750,000, including both direct and indirect costs, for the first 12-month budget period. An applicant may request a project period of up to three years. An applicant may request up to $1 million for the first 12-month budget period if the applicant addresses optional objective 5. All other applications will be limited to maximum request of $750,000 for each 12-month period. Total funding of approximately $11 million is anticipated.

MU Deadline:

4:00 p.m., Friday, January 11, 2008

Sponsor Deadlines:

February 4, 2008

URL for more information:

This notice is being sent to deans, directors, and chairs in health science disciplines. Please forward it to faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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