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Limited Submission Announcements

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The National Institutes of Health are inviting new and/or competing continuation applications from teams of institutions to participate in a clinical trials program to improve graft acceptance and patient/graft survival in pediatric organ transplant recipients, i.e., children up to 20 years of age who have undergone heart, lung, liver, kidney or intestinal transplantation. The Clinical Trials in Organ Transplantation in Children (CTOT-C) program will support a cooperative, multi-institutional consortium for the conduct of interventional or observational clinical studies with associated mechanistic studies to further our understanding of and ultimately reduce the immune-mediated morbidity and mortality in pediatric transplant recipients. These studies will be designed to: (1) evaluate new therapies and approaches to overcome immunologic barriers to graft acceptance and/or long-term graft and patient survival; (2) evaluate novel approaches to treatment or prevention of immune mediated complications in pediatric transplant patients; (3) investigate underlying mechanisms of action for pathological processes and therapeutic regimens under evaluation; and (4) develop diagnostic tests and critical biomarkers that will facilitate routine surveillance, early diagnosis and ongoing monitoring of those processes that contribute to post-transplant morbidity and mortality.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 4:00 pm Friday, February 16, 2007. Letters of intent should be limited to a 3-page summary outlining 1) the institutions and key personnel expected to participate, 2) the proposed clinical trial(s), and 3) the associated mechanism of disease and/or therapeutic action studies.


Direct costs up to $800,000 per year for up to five years fro 3 or 4 awards

MU Deadline:

4:00 p.m., Friday, February 16, 2007

Sponsor Deadline:

May 14, 2007 (non-required letters of intent)

June 13, 2007 (application deadline)

URL for more information:

This notice is being sent to deans, directors, and chairs in health science disciplines. Please forward it to faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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