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Limited Submission Announcements

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The NIH Genome-Wide Association Studies in the Genes and Environment Initiative - Genotyping Facilities (U01) supports facilities to genotype samples from human subjects on whom information is available for conditions/traits of public health importance and relevant environmental exposures for genome-wide association (GWA) genotyping and replication studies, as part of the Genes and Environment Initiative.

Each Genotyping Facility will provide rapid, cost-effective, state-of-the-art, high-throughput genotyping to capture at least 80% of inter-individual genomic variation in roughly 12,000 specimens in a three-year period. Roughly 60% of this genotyping will be conducted in the first year, 20% in the second year, and 20% in the third year. Costs of genotyping are expected to decline substantially during the course of this project, so it may be possible to increase the number of studies supported by the GEI-GWA program. Applicants should provide and justify their own projections about cost expectations over the three-year period of performance, and describe what they will do to push costs downward. In addition, applicants should describe the genotyping quality standards that they currently maintain and expect to maintain during the course of the program, including genotype call rates, concordance with HapMap samples, and proportion of SNPs failing Hardy-Weinberg equilibrium. Approaches for receiving, tracking, and preparing samples received from Study Investigators should be described and approaches for minimizing sample errors detailed. Processes for assessing sample handling and quality at the submitting sites, and steps to be taken for samples that fail these assessments, should also be described.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 5:00 pm Friday, September 22, 2006. Letters of Intent should be limited to two pages and should summarize 1) the facilities and expertise to be tapped for the project, 2) expected genotyping quality standards, and 3) approaches for receiving, tracking, and preparing samples and minimizing sample errors.


Up to $6,000,000 direct costs for the full project period of up to four years.

MU Deadline: 4:00 p.m., Friday, September 22, 2006
Sponsor Deadline:

Letters of Intent (optional) due November 1, 2006
Full proposal due November 29, 2006

URL for more information:

This notice is being sent to deans, directors, and chairs in life science disciplines. Please forward it to other faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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