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Limited Submission Announcements

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The National Institute of General Medical Sciences (NIGMS) is inviting applications for Centers for the Determination of Structures of HIV/Host Complexes (P50). The goal of this announcement is to attract the best scientists in relevant fields to attack the problem of the structure determination of HIV/host macromolecular complexes. Hence the application should focus on the specific problems to be solved, approaches to be used, identification of potential bottlenecks, a workable management plan along with milestones, and the commitment and past experience of the investigators. The research being proposed is expected to push the boundaries of what is feasible. As such, it is recognized that aspects of the plan necessarily will be highly risky. Characteristics of each center:

  1. Each center must have the demonstrated capabilities for the high-resolution structure determination of macromolecular complexes.
  2. Each center must have a focus of investigation within the broader biology of HIV/host cell interactions. This focus will help to guide selection of structure determination targets.
  3. Each center must actively collaborate with the biological community engaged in research on HIV/host complexes.
  4. Each center is strongly encouraged to have a technology component designed to push the state-of-the-art in the cloning, expression and structure determination of HIV/host complexes.
  5. Alternatively or in addition to item 4 above, a center may propose to study the role and/or activity of certain complexes in vivo using state-of-the-art biophysical techniques.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 5:00 pm Friday, June 15, 2006. Letters of intent should be limited to three pages and should summarize 1) the focal theme of the center, 2) each of the anticipated research projects and cores, and 3) planned collaborations with the biological community engaged in research on HIV/host complexes.


An applicant may request a project period of up to five years and a budget for direct costs of up to $2.7 million per year and total costs up to $4 million per year.

MU Deadline: 5:00 p.m., Monday, June 15, 2006 (letter of intent)
Sponsor Deadline:

January 12, 2007 (full proposal)

URL for more information:

This notice is being sent to deans, directors, and chairs in biomedical disciplines. Please forward it to other faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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