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Limited Submission Announcements

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The NIH National Institute of Allergy and Infectious Diseases (NIAID) has issued a request for applications for Tropical Medicine Research Centers to be focused on diseases caused by the parasites of the Trypanosomatidae family: Leishmaniasis, Chagas' Disease, and Human African Trypanosomiasis. This funding opportunity will use the Specialized Center (P50) award mechanism. This mechanism supports all phases of research ranging from basic and developmental aspects to applied field and clinical research.

These diseases remain constant threats to the lives of humans throughout large areas of Africa, Asia, and South America. Depending upon individual strains of the parasites, diseases caused by these organisms can last for weeks to years and can be fatal if left untreated. At present, there are no vaccines against these diseases and treatment options are limited. The treatments that exist are often associated with severe side effects and toxicities. Furthermore, in some instances, parasites have been reported to be resistant to drug treatment. These diseases are a major public health threat for people living in tropical and subtropical regions of the world and are responsible for limiting individual productivity and socioeconomic development.

With the recent sequencing of the trypanosomatid genomes, new scientific opportunities are expected to emerge in the areas of diagnostics, therapeutics, vaccine development, immunopathogenesis, immunogenetics, epidemiology, resistance patterns, susceptibility of cohorts, and vector biology, which will lead to or result in new tools or strategies for diagnosis, prevention, amelioration, and/or treatment of diseases caused by the trypanosomes.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 5:00 pm Friday, June 2, 2006. Letters of intent should be limited to three pages and should include a brief summary of  each of the research projects and core facilities anticipated for the center, along with the names of the investigators likely to lead each component.


The estimated total funds available for the first year of support for this RFA will be $2.6 million. In fiscal year 2007, the NIAID plans to fund approximately three to four TMRCs under this RFA. This level of support is dependent on the receipt of a sufficient number of applications of high scientific merit.

MU Deadline: 5:00 p.m., Friday, June 2, 2006 (letter of intent)
Sponsor Deadline:

June 21, 2006 (letter of intent due date, requested but not required)
July 21, 2006 (full application due data)

URL for more information:

This notice is being sent to deans, directors, and chairs in life science disciplines. Please forward it to faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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