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Limited Submission Announcements

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NIH seeks applications for Genome Sequencing Centers, which will constitute the renewal of the National Human Genome Research Institute (NHGRI) large-scale sequencing program. Since the completion of the human genome sequence, much of the NHGRI-supported large-scale sequencing capacity has been directed toward comparative genomic sequencing projects to generate data for annotating the human genome and informing fundamental questions about genome evolution. Over the next few years, NHGRI expects that these activities will continue while an increasing fraction of the sequencing capacity will be directed to medical sequencing, which is expected to result in the identification of genomic changes implicated in heritable disease and the elucidation of the genetic changes associated with cancer. The program will also increase its attention to the genomic sequencing of eukaryotic pathogens and vectors of human disease.

NHGRI intends to support centers that are capable of generating a variety of useful genomic sequence products and have the flexibility to evolve to handle a broad range of projects and to implement new technologies. In the next phase of the NHGRI sequencing program, the Institute is also looking to support centers that will be repositories of knowledge about how to develop and use sequence information and how to disseminate that knowledge.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 5:00 pm Friday, February 3, 2006. Letters of intent should be limited to a 3-page summary including 1) plans for driving the state of the art and continuing gains in the efficiency of genomic sequencing; 2) any plans for implementing new sequencing technologies; 3) past record of technology development and implementation; 4) plans for data release; and 5) specific plans in the area(s) of medical sequencing, cancer genome sequencing, normal human variation, comparative genome sequencing, parasite and vector genomes, new model systems and/or other areas.

Amount: Will use the U54 cooperative agreement award mechanism
MU Deadline: 5:00 p.m., Friday, February 3, 2006 (letter of intent)
Sponsor Deadline:

April 11, 2006

URL for more information:

This notice is being sent to deans, directors, and chairs in life science disciplines. Please forward it to faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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