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Limited Submission Announcements

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The NHLBI Exploratory Program in Systems Biology (R33) program seeks to apply systems biology approaches to innovative, high-risk, high-impact research on heart, lung, blood, and sleep (HLBS) physiology and pathophysiology by multidisciplinary teams of investigators. For the purposes of this program, “systems biology” is defined as an approach to explaining and predicting complex cellular and physiological phenomena of living organisms in terms of underlying physical and chemical processes and accompanying feedback regulations at molecular, cellular, tissue, or whole organ levels. This systems biology approach will combine mathematical modeling and simulation to complement the traditional empirical and experimental approach of biomedical research. Mathematical modeling and simulation may range from the molecular scale through to organ scale models. These models and simulations will be driven by empirical observations and will generate specific, explicitly testable predictions that will enable refinement of the models in response to experimental validation.

This program will support projects that integrate multi-investigator, multidisciplinary approaches and have a high degree of interplay between computational and experimental approaches. Proposals responsive to this RFA must be submitted as a cluster of two or more applications, with a minimum of one application for a computational/modeling component and one application for a biomedical/experimental component of the cluster.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office ofResearch,, no later than 5:00 pm Friday, January 20, 2006. Letters of intent should be limited to 3 pages and should 1) list the projects and associated PIs to be included in the application, 2) summarize the computational/modeling component of the application, and 3) summarize the biomedical/experimental component of the application.

Amount: Applicants may request up to $600,000 in direct costs per cluster in each year; this total excludes F&A costs of consortium subcontracts.
MU Deadline: 5:00 p.m., Friday, January 20, 2006 (letter of intent)
Sponsor Deadline:

Non-required letters of intent are due by February 8, 2006.
The deadline for submission of applications is March 10, 2006.

URL for more information:

This notice is being sent to deans, directors, and chairs in life science, engineering and physical science disciplines. Please forward it to faculty members who may be interested.

All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at

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