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Limited Submission Announcements

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The Burroughs Wellcome Fund (BWF) Investigators in Pathogenesis of Infectious Disease program provides new opportunities for accomplished investigators still early in their careers to study pathogenesis, with a focus on the intersection of human and pathogen biology. The program is intended to shed light on the overarching issues of how human hosts handle infectious challenge. BWF is particularly interested in work focused on the host, as well as host-pathogen studies originating in viral, bacterial, fungal, or parasite systems. Studies in this area may have their root in the pathogen, but the focus of the work should be on the effects on the host at the cellular and/or systemic levels. Excellent animal models of human disease are within the scope of the program.

The grants are intended to give recipients the freedom and flexibility to pursue new avenues of inquiry and higher-risk research projects that hold potential for advancing significantly the biochemical, pharmacological, immunological, and molecular biological understanding of how infectious agents and the human body interact. Research on under-studied pathogens including fungi, metazoan and protozoan parasites, and emerging viruses, is especially of interest. Potential frameworks for proposals include the following:

  • Cell-pathogen interactions--studies of host cell responses at the cell surface, cell signaling in response to infection, microbial persistence in host cells, and other processes occurring at the level of the host cell.
  • Host-pathogen interactions--studies on the genetics of the host as it influences resistance and susceptibility to infectious disease, as well as innate and adaptive immune responses to infectious agents and pathogen modulation of the immune system.
  • Novel routes to disease causation in humans--studies of the role of infectious agents in the etiology of chronic diseases and as triggers of immunologic and autoimmune disease.

Because MU is limited in the number of applications it may make, letters of intent must be submitted to the Office of Research, 203 Jesse Hall by 5:00 pm Friday, April 22, 2005.  Letters if intent should be limited to three pages and should include a description of the proposed research, its objectives, and a budget outline.

Amount: $400,000 total over a period of 5 years.
MU Deadline: 5:00 pm, Friday, April 22, 2005
Foundation Deadline: November 1, 2005

URL for more information:

This notice is being sent to deans, directors, and chairs in life science disciplines. Please forward it to faculty members who may be interested.


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