Office of Grant Writing & Publications.

NIH Mendelian Disorders Genome Centers (U54)

Office of Grant Writing & Publications

202 Jesse Hall
University of Missouri
Columbia, MO 65211

573 882-9500 phone
573 884-8371 fax

Limited Submission Announcement

The National Institutes of Health (NIH) Mendelian Disorders Genome Centers (U54) program seeks to use genome-wide sequencing and other genomic approaches to discover the genetic variants underlying Mendelian disorders and other health-related Mendelian phenotypes in humans. The centers should aim to uncover the genetic basis for as many of these phenotypes as possible. More generally, the National Human Genome Research Institute (NHGRI) intends that this effort will provide a foundation for the broader research community to elucidate the genetic basis of all Mendelian disorders, and to that end this FOA has two additional purposes: First, this FOA seeks to establish and refine the most effective and efficient designs, technologies, and analysis methods for elucidating the genetic basis of Mendelian phenotypes. Second, this FOA seeks to support the effort to create an annotated public list of existing samples as a resource for investigators interested in studying the phenotypes that they represent.

Because MU is limited to one application for this program, letters of intent must be submitted to the Office of Research,, no later than 4:00 p.m. on Friday, January 14, 2011. Letters of intent should be limited to three pages and should include 1) goals and objectives of the proposed program, 2) a description of how a state-of-the-art genome center will be established and operated to fulfill its research objectives, 3) how the proposed program will further NHGRI's goals related to Mendelian disorders, and 4) the names of three MU personnel who could serve as internal reviewers for letters of intent under this program.


Up to $10 million per year in direct costs for up to four years.

Campus Deadline for Letter of Intent:

4:00 p.m., Friday, January 14, 2011.

External Proposal Deadlines:

A non-required letter of intent is due February 3, 2011.
Application deadline is March 3, 2011.

URL for more information


All limited submission announcements can be tracked by deadline via the Calendar at or by announcement date via the Limited Submissions listing at