Institutional Review Board
IRB Reliance Procedures – Investigator Responsibilities
The University of Missouri engages in agreements in which an IRB relies on the review of a designated IRB known as the “IRB of Record” in multi-site research studies. These agreements may be altered and vary in scope and terms. They are designed to reduce duplication of review efforts and increase efficiency by designating an IRB of Record with one IRB initial and continuing review process.
Not every multi-site study requires a reliance agreement and these determinations are made by the IRB. The institutions entering into an agreement must be engaged in research. In general, an institution is engaged when its employees or agents for the purposes of the research project obtain: (1) data about the subjects of the research through intervention or interaction with them; (2) identifiable private information about the subjects of the research; or (3) the informed consent of human subjects for the research. Contact the IRB for assistance with this determination.
Office of Human Research Protections Guidance on Engagement: http://www.hhs.gov/ohrp/policy/engage08.html
Click on the Appropriate Scenario to view Instructions and Responsibilities:
Scenario 1: MU IRB is the IRB of Record – Submission Process
Scenario 2: MU IRB Relying on Another IRB – Submission Process
Scenario 3: Adding an Individual with No IRB Affiliation