CRISPR-Cas9 off-target analysis. Off-target prediction software is used to determine the most probable off-target gRNA binding sites. These potential off-target sites are fully sequenced to ensure no mutations occur due to erroneous CRISPR/Cas9 activity.
The Animal Modeling Core provides a variety of essential services associated with the generation and characterization of animal models.
AMC personnel provide expert advice on the design and approach used for generating animal models.
The AMC utilizes traditional approaches to generate models such as embryonic stem cell modification as well as uses cutting-edge genetic modification tools such as the CRISPR/Cas9 system.